The landscape of medical weight loss has changed dramatically in recent years, with new medications offering unprecedented results for patients struggling with obesity.
GLP-1 receptor agonists, including semaglutide (Wegovy) and tirzepatide (Mounjaro), have transformed obesity treatment. These injectable medications work by mimicking natural hormones that regulate appetite and metabolism, leading to significant and sustained weight loss in clinical trials.
Lifestyle-based weight management programmes remain the foundation of any treatment plan. These typically include personalised dietary guidance, structured exercise programmes, behavioural change support, and regular monitoring by a healthcare team.
For patients with severe obesity (BMI ≥ 40, or BMI ≥ 35 with obesity-related conditions), bariatric surgery may be the most effective option. Procedures like gastric sleeve and gastric bypass have been shown to produce lasting weight loss and significant improvement in conditions such as Type 2 diabetes and hypertension.
The choice of treatment depends on individual factors including BMI, medical history, previous weight loss attempts, and personal preferences. A specialist endocrinologist can help you navigate these options and develop a personalised plan.
Whatever approach you choose, ongoing support and follow-up are essential for maintaining weight loss long term. Weight management is a journey, not a destination, and having the right medical team behind you makes all the difference.
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Dr Asif Malik Humayun is available for consultations. Get personalised advice from an experienced endocrinologist.

