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Novel Weight-Loss Treatments

Obesity Research & Innovation

Helping develop the next generation of weight-management treatments. Dr Asif Malik Humayun combines extensive clinical experience with active Principal Investigator involvement in clinical research evaluating innovative obesity treatments.

Research & Development

Helping Develop the Next Generation of Weight-Management Treatments

Dr Asif Malik Humayun combines extensive clinical experience in obesity medicine with active involvement in clinical research evaluating innovative approaches to weight management.

He has served as Principal Investigator in clinical studies investigating SIRONA, a novel orally administered, gastro-retentive hydrogel treatment designed to support weight loss by promoting satiety and reducing dietary intake.

His involvement has included first-in-human research assessing safety, feasibility and tolerability, followed by proof-of-concept evaluation of efficacy and potential application in maintaining weight loss following GLP-1 treatment.

Clinical Research Programme

The SIRONA Research Programme

SIRONA is an investigational oral hydrogel treatment being studied as a potential non-systemic approach to weight management. Unlike medicines that act through absorption into the bloodstream, the investigational hydrogel is designed to expand within the gastrointestinal tract and promote a feeling of fullness.

The research programme has explored:

Safety and tolerability
Feasibility of oral administration
Effects on appetite and dietary intake
Preliminary weight-loss efficacy
Calorie-seeking behaviour
Weight management in women of perimenopausal age
Potential maintenance of weight loss following GLP-1 therapy
The role of non-injectable treatments within long-term obesity care

Important: SIRONA remains an investigational treatment and is not currently being offered as part of routine clinical care.

Dr Humayun's Role

As Principal Investigator, Dr Humayun has played a central clinical role in the delivery and evaluation of the SIRONA research programme. His responsibilities have included patient assessment, clinical oversight, treatment safety, interpretation of clinical outcomes and collaboration with the wider research team.

His involvement in both first-in-human and subsequent proof-of-concept research reflects his commitment to developing practical, scientifically robust treatments for people living with obesity.

Pioneering clinical involvement in the evaluation of novel weight-loss treatments
Research Credentials

Selected Research Involvement

Principal Investigator: SIRONA first-in-human clinical study
Principal Investigator: SIRONA proof-of-concept weight-loss study
Research into maintaining weight loss following GLP-1 therapy
Peer-reviewed SIRONA trial publication
Research presented at the European Congress on Obesity
Research presented at ObesityWeek
Research submitted or presented at the UK Congress on Obesity
Research into appetite, dietary intake and calorie-seeking behaviour
Investigator in diabetes, cardiovascular and metabolic clinical studies

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Publications

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Reads

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Citations

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Experience consultant-led care informed by extensive clinical practice and active involvement in obesity research.